Departamento de Bioquímica

Faculdade de Medicina da Universidade do Porto


Alvelos M, Pimentel R, Pinho E, Gomes A, Lourenço P, Teles MJ, Almeida P, Guimarães JT, Bettencourt P (2011)  Neutrophil gelatinase-associated lipocalin in the diagnosis of type 1 cardio-renal syndrome in the general ward. Clin  J Am Soc Nephrol. 6:476-81

Andrade F, Silva JP, Carvalho M, Castanheira E, Soares R, Gama M (2011) Studies on the hematocompatibility of bacterial cellulose. J Biomed Mat Res 98: 554- 66 (IF= 3.318)

Araújo JR, Gonçalves P, Martel F (2011) Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr Res 31:77-87 (IF=2.092)

Bidarra S, Barrias C, Fonseca K, Barbosa MA, Soares R, Granja P (2011) Injectable in situ crosslinkable RGD-modifie alginate matrix for endothelial cells delivery. Biomaterials 32: 7897-7904. (IF= 7.822)

Bidarra SJ, MA, Soares R, Amédée J, Granja P (2011) Phenotypic and proliferative modulation of human mesenchymal stem cells via crosstalk with endothelial cells. Stem Cell Res 7: 186-197 (IF= 3.388)

Castela A, Soares R, Rocha F, Vendeira P, Costa C (2011) Microarray screening of angiogenic gene alterations in diabetic cavernosal tissue. Sexologies 20:251-254

Castela A, Soares R, Rocha F, Vendeira P, Virag R, Costa C (2011) Erectile tissue molecular alterations with aging – differential activation of the p42/p44 MAP kinase pathway. Age 33: 119-30. (IF= 6.280)

Faria A, Calhau C (2011) The bioactivity of pomegranate: impact on health and disease. Crit Rev Food Sci Nutr 51(7):626-34.

Faria A, Pestana D, Teixeira D, Couraud PO, Romero I, Weksler B, de Freitas V, Mateus N, Calhau C (2011) Insights into the putative catechin and epicatechin transport across Blood-Brain Barrier. Food & Function 2, 1:39-44.

Fraga H, Fontes R (2011) Enzymatic synthesis of mono and dinucleoside polyphosphates. Biochim Biophys Acta 1810: 1195-1204

Gonçalves P, Araújo JR, Martel F (2011) Characterization of butyrate uptake by non-transformed intestinal epithelial cell lines. J Memb Biol 240:35–46 (IF=1.63)

Gonçalves P, Araújo JR, Pinho MJ, Martel F (2011) In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds. Nutr Cancer 63:282–294 (IF=2.553)

Gonçalves P, Gregório I, Martel F (2011) The short-chain fatty acid butyrate is a substrate of breast cancer resistance protein (BCRP). Am J Physiol Cell Physiol 301:C984-94 (IF=3.817)

Keating E, Araújo JR, Martel F (2011) The placental transport of folates: interference by xenobiotics and pathological conditions. Canal BQ 8:44-48

Kozmus C, Moura E, Serrão MP, Real H, Guimarães JT, Guedes-de-Pinho P, Duarte BP, Marques H, Martins MJ, Vieira-Coelho MA (2011) Influence of dietary supplementation with dextrin or oligofructose on the hepatic redox balance in rats. Mol Nutr Food Res 55:1735-9. (IF: 4.71)

Lopes F, Rocha A, Pirraco A, Regasini L, Siqueira J, Silva D, Bolzani V, Carlos I, Soares R (2011) Alchornea gladulosa ethyl-acetate fraction exhibits anti-angiogenic activity: preliminary findings from in vitro assay using HUVEC. J Med Food 14: 1244-53 (IF= 1.34)

Ramalho R, Soares R, Couto N, Moreira A (2011) Tachykinin receptors antagonism for asthma: a systematic review. BMC Pulm Med 11: 41-47 (IF=1.33)

Ramos R, Silva JP, Costa R, Guardão L, Schmitt F, Soares R, Vilanova M, Domingues L, Gama M (2011) Wound healing activity of the human antimicrobial peptide LL37. Peptides 32: 1469- 76. (IF= 2.705)

Soares R, Meireles M, Rocha A, Pirraco A, Obol D, Alonso E, Joos G, Balogh G (2011) Maitake D-fraction mushroom extract induce apoptosis in breast cancer cells by BAK-1 gene activation. J Med Food 14: 563- 72. (IF= 1.34)

Visioli F, Alarcón de la Lastra C, Andres-Lacueva C, Aviram M, Calhau C, Cassano A, d’Archivio M, Faria A, Favé G, Fogliano V, Llorach R, Vitaglione P, Zoratti M, Edeas M (2011) Polyphenols and human health: a prospectus. Crit Rev Food Sci Nutr 51:524-546.

Andrade F, Costa R, Domingues L, Soares R, Gama M. Improving bacterial cellulose for blood vessel replacement: Functionalization with a chimeric protein containing a cellulose-binding module and an adhesion peptide. Acta Biomaterialia 2010; 6: 4034-41. (IF= 3.727).

Araújo JR, Gonçalves P, Martel F. Characterization of uptake of folates by rat and human blood-brain barrier endothelial cells. BioFactors. 2010; 36: 201-209 (IF 0.912).

Azevedo J, Iva Fernandes, Ana Faria, Joana Oliveira, Ana Fernandes, Victor de Freitas, Nuno Mateus (2010) Antioxidant properties of anthocyanidins, anthocyanidin-3-glucosides and respective portisins. Food Chemistry 119, 518-523 (IF= 3.146).

Barbosa VM, Miles EA, Calhau C et al. Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial. Crit Care. 2010;14(1):R5.(IF - 4.931).

Bidarra S, Barrias C, Barbosa M, Soares R, Granja P (2010). Immobilization of human mesenchymal stem cells within injectable RGD-grafted alginate microspheres and assessment of their angiogenic potential. Biomacromolecules 2010; 11: 1956-64. (IF= 4,146).

Botelho M, Soares R, Vale N, Ribeiro R, Camilo C, Almeida R, Medeiros R, Gomes P, Machado JC, Costa JM. Schistosoma haematobium: Identification of new estrogenic molecules with estradiol antagonist activity and ability to inactivate estrogen receptor in mammalian cells. Exp Parasitol 2010; 126: 526-35 (IF= 1,751).

Faria A, Pestana D, Teixeira D, et al. Blueberry anthocyanins and pyruvic acid adducts: anticancer properties in breast cancer cell lines. Phytother Res 2010;24(12):1862-9. (IF - 1.746).

Faria A, Monteiro R, Pestana D, et al. Impact of culture media glucose levels on the intestinal uptake of organic cations. Cytotechnology. 2010;62(1):23-9. (IF – 0.977).

Faria A, Pestana D, Teixeira D, et al. Flavonoid transport across RBE4 cells: A blood-brain barrier model. Cell Mol Biol Lett. 2010;15(2):234-41. (IF – 1.127).

Ferreira J, Monteiro R, Canedo A, et al. The role of adipose tissue in coronary atherosclerosis. Minerva Cardioangiologica, 2010, 58(3) 423 (publicação indexada no Pubmed, sem IF).

Fernandes I, Faria A, Azevedo J, et al. Influence of anthocyanins, derivative pigments and other catechol and pyrogallol-type phenolics on breast cancer cell proliferation. J Agric Food Chem. 2010 24;58(6):3785-92. (IF – 2.469).

Gião MS, Pestana D, Faria A, et al. Effects of extracts of selected medicinal plants upon hepatic oxidative stress. J Med Food. 2010 Feb;13(1):131-6. (IF: 1.39).

Gonçalves P, Araújo JR, Martel F. Effect of some natural mineral waters in nutrient uptake by Caco-2 cells. Int J Vitam Nutr Res. 2010; 80: 131-43 (IF 0.897).

Martel F, Monteiro R, Calhau C Effect of polyphenols on the intestinal and placental transport of some bioactive compounds. Nutr Res Rev. 2010 ;23(1):47-64. (IF – 1.593).

Melo A, Gorgal-Carvalho R, Amaral J, et al. Clinical management of paroxysmal nocturnal haemoglobinuria in pregnancy: three case reports. Blood Transfus. 2010 Sep 16. doi: 10.2450/2010.0024-10. [Epub ahead of print] (indexada no Pubmed, sem IF).

Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators of Inflammation. 2010, doi:10.1155/2010/289645 (IF – 2.019).

Moura V, Monteiro R. Papel do tecido adiposo na inflamação e metabolismo do doente obeso. Alimentação Humana, 2010, 16(1):15-22.

Negrão R, Soares R. Platelet-mediated flavonoid metabolism. Interaction with vascular wall cells and implication in vasculopathy. PlOS ONE 2010; 5: e9673. (IF= 4,351).

Negrão R, Costa R, Duarte D, Taveira T, Mendanha M, Moura L, Vasques L, Azevedo I, Soares R. Angiogenesis and inflammation signaling are targets of beer polyphenols o vascular cells. J Cell Biochem 2010; 111: 1270-9 (IF= 3,540).

Pinto CE, Moura E, Serrão MP, et al. Effect of (-)-delta(9)-tetrahydrocannabinoid on the hepatic redox state of mice. Braz J Med Biol Res 2010; 43: 325-9 (IF: 1.075).

Pirraco A, et al. Imatinib targets PDGF signaling in melanoma and host smooth muscle neighboring cells. J Cell Biochem 2010; 111: 433-41. (IF= 3,540).

Santos A, Martins MJ, Guimarães JT, et al. Sodium-rich carbonated natural mineral water ingestion and blood pressure. Rev Port Cardiol. 2010 Feb;29(2):159-72 (indexada no Pubmed, sem IF).

Santos-Antunes J, Fontes R. Glicogenose Tipo I. Disfunção do Complexo Glicose-6-fosfátase. Arq Med. 2009; 23: 109:118 (embora de 2009, é referido aqui pois não o foi no relatório de 2009).

Silva E, Pinto V, Simão S, Serrão MP, Afonso J, Amaral J, Pinho MJ, Gomes P, Soares-da-Silva P. Renal aging in WKY rats: changes in Na+,K+ -ATPase function and oxidative stress. Exp Gerontol 2010; 45(12): 977-83 (IF2009=3.342).

Simão S, Gomes P, Jose PA, Soares-da-Silva P. Increased responsiveness to JNK1/2 mediates the enhanced H2O2-induced stimulation of Cl-/HCO3- exchanger activity in immortalized renal proximal tubular epithelial cells from the SHR. Biochem Pharmacol 2010; 80(6): 913-9 (IF2009=4.254).

Simundic AM, Bilic-Zulle L, Nikolac N, et al. The quality of the extra-analytical phase of laboratory practice in some developing European countries and Mexico - a multicentric study. Clin Chem Lab Med. 2010 Dec 1. [Epub ahead of print] (IF: 1.886).

Tavares S, Sousa J, Gonçalves P, et al. The effect of folate status on the uptake of physiologically relevant compounds by Caco-2 cells. Eur J Pharmacol. 2010; 640: 29-37 (IF 2.585).

Teixeira D, Pestana D, Faria A, et al. Modulation of adipocyte biology by δ(9)-tetrahydrocannabinol. Obesity (Silver Spring). 2010 18(11):2077-85. (IF – 3.366).


Araújo JR, Martel F. Regulação da absorção intestinal de glicose. Uma breve revisão. Arq Med (in press)

Gião MS, Pestana D, Faria A, Guimarães JT, Pintado ME, Calhau C, Azevedo I, and Malcata FX. Effects of extracts of selected medicinal plants upon hepatic oxidative stress. J Med Food (in press)

Keating E, Gonçalves P, Campos I, Costa F, Azevedo I, Martel F (2009) Folic acid uptake by the human syncytiotrophoblast: interference by pharmacotherapy, drugs of abuse and pathological conditions. Reprod Toxicol (in press)

Keating E, Gonçalves P, Costa F, Campos I, Azevedo I, Martel F (2009) Comparison of the transport characteristics of bioactive substances in IUGR and normal placentas. Pediatr Res (in press)

Martins MJ, Negrão MR, Azevedo I: A elaboração de um painel de divulgação científica. Educação Médica 2004, 2ª Série, 2 (in press).

Rocha A, Azevedo I, Soares R: Anti-angiogenic effects of imatinib target smooth muscle cells but not endothelial cells. Angiogenesis (in press). DOI: 10.1007/s10456-007-9080-2

Ribeiro L, Martel F, Azevedo I. Somatostatin regulates 3H-1-methyl-4-phenylpyridinium (3H-MPP+) release from primary cultures of bovine adrenal chromaffin cells via distinct receptor subtypes (submitted)

Santos-Antunes J. & Fontes R. Glicogenose tipo I: disfunção do complexo glicose-6-fosfátase (submetido).


Araújo JR, Gonçalves P, Martel F (2009) Effect of cannabinoids upon the uptake of folic acid by BeWo cells. Pharmacology 83:170-176

Assunção M, Santos-Marques MJ, Monteiro R, Azevedo I, Andrade JP, Carvalho F, Martins MJ (2009). Red Wine Protects against Ethanol-Induced Oxidative Stress in Rat Liver. J Agric Food Chem 57: 6066-6073

Faria A, Monteiro R, Pestana D, de Freitas V, Mateus N, Azevedo I, Calhau C (2009) Intestinal oxidative state can alter nutrient and drug bioavailability. Oxidative Medicine & Cellular Longevity. 2, 5:1-5.

Faria A, Pestana D, Azevedo J, de Freitas V, Azevedo I, Mateus N, Calhau C. (2009) Absorption of anthocyanins through intestinal epithelial cells – putative involvement of GLUT2. Mol Nutr Food Res 9; 1-8.

Fernandes I, Azevedo J, Faria A, Calhau C, de Freitas V, Mateus N (2009) Enzymatic Hemisynthesis of Metabolites and Conjugates of Anthocyanins. J Agric Food Chem J Agric Food Chem. 28;57(2):735-45.

Gonçalves P, Araújo JR, Pinho MJ, Martel F (2009) Modulation of butyrate transport in Caco-2 cells. Naunyn-Schmiedeberg’s Arch Pharmacol 379:325-336

Lemos C, Kathmann I, Giovannetti E, Calhau C, Jansen G, Peters GJ.(2009) Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib. Br J Cancer. 7;100(7):1120-7.

Lemos C, Kathmann I, Giovannetti E, Bellien J, Scheffer GL, Calhau C, Jansen G, Peters GJ. (2009) Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins. Mol Cancer Therap. 8(3):655-64.

Monteiro R, Soares R, Guerreiro S, Calhau C, Azevedo I (2009) Red wine increases adipose tissue aromatase expression and regulates body weight and adipocyte size. Nutrition;25(6):699-705.

Rocha JC, Martel F (2009) Large neutral amino acids supplementation in phenylketonuric patients. J Inherit Metab Dis May 13. [Epub ahead of print]


Alpuim P, Filonovich S, Costa C, Rocha P, Vasilevskiy M, Lanceros-Mendez S, Frias C, Torres Marques A, Soares R, Costa C. (2008) Fabrication of a strain sensor for bone implant failure detection based on piezo-resistive doped nanocrystalline silicon. J Non-Cryst Solids. 354: 2585-9.

Araújo JR Gonçalves P, Martel F (2008) Modulation of glucose uptake in a human trophoblast cell line (BeWo) by dietary bioactive compounds and drugs of abuse. J Biochem 144:177-86.

Azenha MA, Evangelista R, Martel F, Vasconcelos MT (2008) Estimate of the digestibility, assimilability and intestinal permeability of butyltins occurring in wine. Food Chem Toxicol 46:767-773.

Carneiro A, Falcão M, Azevedo I, Falcão Reis F, Soares R. (2008) Multiple effects of bevacizumab in angiogenesis. Hints to its application in age-related macular degeneration. Acta Ophthalmol Scand 87: 517-523.

Carneiro A, Falcão M, Pirraco A, Milheiro-Oliveira P, Falcão-Reis F, Soares R. (2008) Comparative effects of bevacizumab, ranibizumab and pegaptanib at intravitreal dose range on endothelial cells. Exp Eye Res. 2008; 88: 522-527.

Faria A, Pestana D, Monteiro R, Oliveira J, de Freitas V, Azevedo I, Calhau C, Mateus N (2008) Influence of anthocyanins and derivative pigments from blueberry (Vaccinium myrtillus) extracts on MPP+ intestinal uptake: A structure–activity approach.  Food Chem 109(3):587-594.

Fernandes I, Azevedo J, Faria A, Calhau C, de Freitas V, Mateus N. (2008) Enzymatic hemisynthesis of metabolites and conjugates of anthocyanins. J Agric Food Chem (in press).

Fernandes J, Amorim R, Azevedo I, Martins MJ (2008). “Modulation of alkaline phosphatase activity from Saccharomyces Cerevisiae grown in low or high phosphate medium”. Braz J Med Biol Res 41:  41-46. 

Fontes R, Fernandes D, Peralta F, Fraga H, Maio I, Esteves da Silva JC (2008) Pyrophosphate and tripolyphosphate affect firefly luciferase luminescence because they act as substrates and not as allosteric effectors. Febs J. 275, 1500-9.

Gonçalves P, Araújo JR, Martel F (2008) The effect of high glucose upon SERT, the human plasmalemmal serotonin transporter. Nutr Neurosci 11:244-50.

Gonçalves P, Araújo JR, Azevedo I, Martel F (2008) Lack of significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells. Pharmacology 82:30-7.

Keating E, Lemos C, Gonçalves P, Azevedo I, Martel F (2008) Acute and chronic effects of some dietary bioactive compounds on folic acid uptake and on the expression of folic acid transporters by the human trophoblast cell line BeWo. J Nutr Biochem 19:91-100.

Keating E, Martel F (2008) Placental transport of folate and thiamine: mini-review. Curr Women Health Rev 4: 141-6.

Lemos C, Kathmann I, Giovannetti E, Dekker H, Scheffer GL, Calhau C, Jansen G, Peters GJ (2008) Folate deprivation induces BCRP expression and mitoxantrone resistance in Caco-2 cells. Int J Cancer 1;123(7):1712-20.

Mendes V, Monteiro R, Pestana D, Teixeira D, Calhau C, Isabel I (2008) Xanthohumol Influences Preadipocyte Differentiation: Implication of Anti-proliferative and Apoptotic Effects. J. Agric Food Chem. 56:11631-7.

Monteiro R, Assunção M, Andrade JP, Neves D, Calhau C, Azevedo I. (2008) Chronic green tea consumption decreases body mass, induces aromatase expression and changes proliferation and apoptosis in adult male rat adipose tissue. J Nutr 138: 2156-63.

Monteiro R, Calhau C, Guerreiro S, Gartner F, Oliveira e Silva A, Pinheiro-Silva S, Azevedo I, Soares R. (2008) Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts. J Cell Biochem. 104: 1699-707.

Monteiro R, Calhau C, Oliveira-e-Silva A, Pinheiro-Silva S, Guerreiro S, Gärtner F, Azevedo I, Soares R (2008) Inflammatory factor production and angiogenesis are inhibited by xanthohumol in breast cancer xenografts. J Cell Biochem 104:1699-707.

Monteiro R, Faria A, Mateus N, Calhau C, Azevedo I (2008) Red wine interferes with oestrogen signalling in rat hippocampus. Journal of Steroid Biochemistry and Molecular Biology 111(1-2):74-9.

Mota A, Silva P, Neves D, Lemos C, Calhau C, Torres D, Martel F, Fraga H, Ribeiro L, Alçada MNMP, Pinho MJ, Negrão MR, Pedrosa R, Guerreiro S, Guimarães JT, Azevedo I, Martins MJ (2008) Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity. Braz J Med Biol Res 41:600-9.

Rocha A, Azevedo I, Soares R. (2008) Progesterone sensitizes breast cancer MCF7 cells to imatinib inhibitory effects. J Cell Biochem. 103: 607-14.

Santos A, Gonçalves P, Araújo JR, Martel F (2008) Intestinal permeability to glucose after traumatic brain injury: effect of gadopentetate dimeglumine administration. Basic Clin Pharmacol Toxicol 103:247-54.


Costa C, Incio J, Soares R (2007) Angiogenesis and chronic inflammation: cause or consequence? Angiogenesis 10: 149-166.

Faria A, Monteiro R, Mateus N, Calhau C, Azevedo I (2007) Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress. Eur J Nutr. 46: 271-278.

Guerreiro S, Monteiro R, Martins MJ, Calhau C, Azevedo I, Soares R (2007) Distinct modulation of alkaline phosphatise isoenzymes by 17β-estradiol and xanthohumol in breast cancer MCF-7 cells. Clin Biochem 40: 268-273.

Keating E, Gonçalves P, Lemos C, Costa F, Smith SB, Bridges CC, Martel F (2007) Progesterone inhibits folic acid transport in human trophoblasts. J Membr Biol [Epub ahead of print].

Keating E, Lemos C, Gonçalves P, Martel F (2007) Acute and chronic effects of some dietary compounds on folic acid uptake and on the expression of folic acid transporters by the human trophoblast cell line BeWo. J Nutr Biochem [Epub ahead of print].

Lemos C, Peters GJ, Jansen G, Martel F, Calhau C (2007) Modulation of folate uptake in cultured human adenocarcinoma Caco-2 cells by dietary compounds. Eur J Nutr 46: 329-336.

Martins MJ, Negrão MR, Azevedo I (2007) Watermelon: the value of higher plasma arginine concentrations. Nutrition 23: 517.

Monteiro R, Calhau C, Azevedo I (2007) Obstructive sleep apnoea and adipocyte death. Eur J Heart Fail 9: 103-104.

Monteiro R, Faria A, Azevedo I, Calhau C (2007) Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids. J Steroid Biochem Mol Biol. 105:124-130.

Ribeiro L, Martel F, Azevedo I (2007) Short-term exposure to somatostatin or muscarinic agonists reduce acetylcholine-induced 3H-MPP+ release from bovine adrenal medullary cells. J Biomed Sci 14: 347-355.

Rocha A, Azevedo I, Soares (2007) Progesterone sensitizes breast cancer MCF7 cells to imatinib inhibitory effects. J Cell Biochem [Epub ahead of print].

Soares R, Azevedo I (2007) Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkB, a downstream effector? Free Radic Biol Med 42: 311.

Soares R, Guerreiro S, Botelho M (2007) Elucidating progesterone effects in breast cancer: Cross talk with PDGF signalling pathway in smooth muscle cells. J Cell Biochem 100: 174-183.


Faria A, Calhau C, Freitas V, Mateus N (2006) Procyanidins as Antioxidants and tumor cell growth modulators. J Agric Food Chem 54: 2392-2397.

Faria A, Mateus N, Freitas V, Calhau C (2006) Modulation of MPP+ uptake by procyanidins in Caco-2 cells: Involvement of oxidation/reduction reactions. FEBS Letters 580: 155-160.

Fraga H, Fernandes D, Novotny J, Fontes R, Esteves da Silva JCG (2006) Firefly luciferase produces hydrogen peroxide as a coproduct in dehydroluciferyl adenylate formation. Chem Bio Chem 7: 929-935.

Keating E, Lemos C, Azevedo I, Martel F (2006) Comparison of folic acid uptake characteristics by human placental choriocarcinoma cells at acidic and physiological pH. Can J Physiol Pharmacol 84: 247-255.

Keating E, Lemos C, Azevedo I, Martel F (2006) Characteristics of thiamine uptake by the BeWo human trophoblast cell line. J Biochem Mol Biol 39: 383-393.

Magro F, Fraga S, Azevedo I, Soares da Silva P (2006) Intestinal 5-hydroxytryptamine and mast cell infiltration in rat experimental colitis. Digestive Diseases and Sciences 51: 495-501.

Martel F (2006) Recent advances on the importance of the serotonin transporter SERT in the rat intestine. Pharmac Res 54: 73-76.

Martel F, Gonçalves P, Azevedo I (2006) Absorption of folate in Caco-2 cells is not affected by high glucose concentration. Eur J Pharmacol 551: 19-26.

Monteiro R, Azevedo I, Calhau C (2006) Modulation of aromatase activity by diet polyphenolic compounds. J Agric Food Chem 54: 3535-3540.

Monteiro R, Becker H, Azevedo I, Calhau C (2006) Effect of hop (Humulus lupulus L.) flavonoids on aromatase (Estrogen synthase) activity. J Agric Food Chem 54: 2938-2943.

Monteiro R, Castro PMST, Calhau C, Azevedo I (2006) Adypocyte size and liability to cell death. Obesity Surgery 16: 804-806.

Negrão MR, Keating E, Faria A, Azevedo I, Martins MJ (2006) Acute effect of tea, wine, beer and polyphenols on ecto-alkaline phosphatase activity in human vascular smooth muscle cells. J Agric Food Chem 54: 4982-4988.

Negrão MR, Mota A, Azevedo I, Martins MJ (2006) Statins and tissue mineralization: putative involvement of alkaline phosphatase. Medical Hypothesis 67:524-528.

Ribeiro L, Martel F, Azevedo I (2006) The release of 3H-1-methyl-4-phenylpyridinium from bovine adrenal chromaffin cells is modulated by somatostatin. Regulatory Peptides 137: 107-113.


Fraga H, Fernandes D, Fontes R, Esteves da Silva JCG (2005) Coenzyme A affects firefly luciferase luminescence because it acts as a substrate and not as an allosteric effector. FEBS Journal  272: 5206-5216.

Fraga H, Fontes R, Esteves da Silva JCG: Synthesis of Lucyferyl Coenzyme A: a bioluminescent substrate for firefly luciferase in the presence of AMP (2005) Angew Chem Int Ed  44: 3427-3429.

Lemos C, Azevedo I, Martel F (2005) Effect of red wine on the intestinal absorption of thiamine and folate in the rat: comparison with the effect of ethanol alone. Alcohol Clin Exp Res 29:664-671.

Monteiro R, Calhau C, Martel F, Faria A (2005) Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells. Naunyn-Schmiedeberg’s Pharmacol  372: 147-152.

Monteiro R, Calhau C, Martel F, Guedes de Pinho P, Azevedo I (2005) Intestinal uptake of MPP+ is differently affected by red and white wine. Life Sciences  76: 2483-2496.

Primo J, Campos M-A, Calhau C (2005) Síndroma de Down e antioxidantes. Nutrícias 5: 37-40.

Sampaio Maia B, Serrão P, Guimarães JT, Vieira-Coelho MA (2005) Renal dopaminergic system activity in the rat remnant kidney. Nephron Exp Nephrol  99: e46-e55.

Santos A, Borges N, Cerejo A, Sarmento A, Azevedo I (2005) Catalase activity and thiobarbituric acid reactive substances (TBARS) production in a rat model of diffuse axonal injury. Effect of gadolinium and amiloride. Neurochem Res  30: 625-631.

Sarmento A, Borges N, Azevedo I (2005) Adrenergic mechanisms and blood-brain barrier permeability. Crit Care Med 33: 1474.

Soares R, Alçada MNMP, Azevedo I (2005) Triggering TGF and Notch signalling cross-talk. BioEssays 27: 763.


Azenha MA, Evangelista R, Martel F, Vasconcelos MT (2004) Estimation of the human intestinal permeability of butylin species using the Caco-2 cell line model. Food Chem Toxicol, 42: 1431-1442.

Borges N, Cerejo A, Santos A (2004) Changes in rat cerebral mitochondrial succinate dehydrogenase activity after brain trauma. Intern J Neuroscience, 114: 217-227.

Costa C, Soares R, Schmitt F (2004) Angiogenesis: now and then. APMIS, 112: 402-412.

Fraga H, Esteves da Silva JCG & Fontes R (2004) Identification of enzyme produced firefly luciferyl-adenylate and the enzyme synthesis of luciferyl-CoA. Chem Bio Chem, 5: 110-115.

Fraga H, Esteves da Silva JCG & Fontes R (2004) Chemical synthesis and firefly produced dehydroluciferyl coenzyme A. Tetrahedron Letters,45:2117-2120.

Keating E, Lemos C, Monteiro R, Azevedo I, Martel F (2004) The effect of a series of organic cations upon the plasmalemmal serotonin transporter, SERT. Life Sci, 76: 103-119.

Martel F, Monteiro R, Lemos C, Vieira-Coelho MA (2004) In vitro and in vivo effect of fluoxetine on the permeability of 3H-serotonin across rat intestine. Can J Physiol Pharmacol, 82: 940-950.

Ribeiro L, Calhau C, Pinheiro-Silva S, Santos A, Alçada M, Guimarães J, Pina A, Maia B, Pereira F, Pimentel F, Lopes H, Santos L, Gonçalves N, Cunha S, Viana P, Almeida J, Lopes A, Azevedo I (2004) Exercício Físico e Insulina, hormona do crescimento e somatostatina. Acta Med Port, 17: 199-204.

Ribeiro L, Martel F, Azevedo I (2004) Effect of somatostatin on the release of adrenaline and noradrenaline from bovine adrenal chromaffin cells. Cell Biology of the Cromaffin Cell, 107-110.

Soares R, Balogh G, Guo S, Gärtner F, Russo J and Schmitt F (2004) Evidence for the Notch signalling pathway on the role of estrogen in angiogenesis. Mol Endocrinol, 18: 2333-2343.

Sucena M, Cachapuz I, Lombardia E, Magalhães A, Guimarães JT (2004) Concentração plasmática de lidocaína durante a broncofibroscopia. Rev Port Pneumol, X: 287-296.


Calhau C, Martel F, Hipólito-Reis C, Azevedo I (2003) Effect of thiamine on 3H-MPP+ uptake by caco-2 cells. Pharmacol Res, 48: 579-84.

Ferreira MA, Bastos A, Martins MJ, Loureiro E (2003) Do envolvimento da Associação de Estudantes e do Conselho Directivo ao surgimento do Gabinete de Educação Médica. Educação Médica, 1: 80-81.

Fraga H, Esteves Da Silva JCG, Fontes R (2003) pH opposite effects on synthesis of dinucleoside polyphosphates and on oxidation reactions catalyzed by firefly luciferase. FEBS Letters, 543: 37-41.

Guimarães JT, Vindis C, Soares-da-Silva P, Parini A (2003) Differential substrate specificity of monoamine oxidase in the rat heart and renal cortex. Life Sci, 73: 955-67.

Guimarães JT, Pereira AS (2003) Normas para a Acreditação e Garantia da Qualidade das Unidades de Saúde utilizadas para o Ensino de Pré-Graduação da Medicina desenvolvidas pela Universidade do Porto. Arq Medicina, 17: 248-9.

Hipólito-Reis C (2003) Stress, equilíbrio e bem-estar na perspectiva do sucesso. Revista Portuguesa de Psicossomática, 5: 9-20.

Hipólito-Reis C (2003) Erotismo no deserto: encenações - a Universidade. Revista Portuguesa de Psicanálise, 24: 35-48.

Hipólito-Reis C (2003) As emergências espiritualistas na grande literatura médica ocidental contemporânea - o espanto do acontecer. Arq Medicina, 17: 206-210.

Martel F, Keating E (2003) Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line: comparison with 5-hydroxytryptamine. Placenta, 24: 361-9

Martel F, Monteiro R, Lemos C (2003) Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (Caco-2) cells occurs through the neuronal serotonin transporter (SERT). J Pharmacol Exp Ther, 306: 355-62.

Martel F, Azevedo I (2003) An update on the extraneuronal monoamine transporter (EMT): characteristics, distribution and regulation. Curr Drug Metab, 4: 313-8.

Negrão MR, Martins MJ, Ramos E, Barros H, Hipólito-Reis C, Azevedo I (2003) Fosfátase alcalina sérica humana e envelhecimento. Acta Médica Portuguesa, 16: 395-400.


Calhau C, Martel F, Pinheiro-Silva S, Pinheiro H, Soares-da-Silva P, Hipólito-Reis C e Azevedo I (2002) Modulation of insulin transport in rat brain microvessel endothelial cells by an ecto-phosphatase activity. J Cell Biochem, 84: 389-400.

Calhau C, Martel F, Hipólito-Reis C e Azevedo I (2002) Modulation of uptake of organic drugs in cultured human colon adenocarcinoma Caco-2 cells by an ecto-alkaline phosphatase activity. J Cell Biochem, 87: 408-416.

Martel F, Gründemann D e Schömig E (2002) A simple method for elimination of false positive results in RT-PCR. J Biochem Mol Biol, 35: 248-250.

Calhau C, Martel F, Soares-da-Silva P, Hipólito-Reis C e Azevedo I (2002) Regulation of 3H MPP+ transport by phosphorylation/dephosphorylation pathways in RBE4 cells: role of ecto-alkaline phosphatase. Naunyn-Schmiedeberg's Arch Pharmacol, 365, 349- 356.

Martel F, Keating E, Calhau C e Azevedo I (2002) Uptake of 3H-1-methyl-4-phenylpyridinium (3H-MPP+) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms. Biochem Pharmacol, 63: 1565-1573.

Ribeiro L, Azevedo I e Martel F (2002) Comparison of the effect of cyclic AMP on the content and release of dopamine and 1-methyl-4-phenylpyridinium (MPP+) in PCI2 cells. Auton Autac Pharmacol, 22, 1-13.

Ribeiro L, Azevedo I e Martel F (2002) Effect of cyclic AMP on PC12 cellular content and release of dopamine and 1-methyl-4-phenylpyridinium. In: The chromaffin cell: transmitter biosynthesis, storage, release, actions, and informatics (O'Connor DT, Eiden LE, eds). Ann NY Acad Sci 971: 539-541.

Ribeiro L, Calhau C, Pinheiro-Silva S, Santos A, Alçada MNMP, Guimarães T, Oliveira A, Riley C, Mota C, Gomes D, Aguiar D, Pinto E, Alencastre H, Pinto M, Ramalho R, Roldão R, Poínhos R, Candeias V, Azevedo I (2002) Influência do tamanho da refeição sobre as concentrações plasmáticas posprandiais de insulina e somatostatina. Alimentação Humana, 8: 13-21.
Departamento de Bioquímica
Faculdade de Medicina da Universidade do Porto
Al. Professor Hernâni Monteiro
4200-319 Porto
tel. (+351) 22 042 66 80
fax (+351) 22 551 36 24

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